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KMID : 0616120070380040308
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 4 p.308 ~ p.311
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Inhibitory potency of Acetylcholinesterase and Amyloid beta(1-42) peptide aggregation to the Extracts of Enthusiasm Reducing herbals
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Kwon Young-Ee
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Abstract
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Inhibition of acetylcholinesterase and amyloid beta(1-42) peptide is good drug targets for Alzheimer’s disease therapeutics. Among the twenty enthusiasm reducing herbals, the 70% methanol extracts (1 mg/ml) of Moutan Radicis Cortex and Forsythiae Fructus showed 91.5% and 85.3% about acethylcholinesterase inhibition, respectively. The extracts (1 mg/ml) of Coptidis Rhizoma and Paeoniae Radix Rubra showed more than 85% inhibition rate against amyloid beta (1-42) peptide aggregation. The neuroprotective effect of the extracts (1 mg/ml) of Moutan Radicis Cortex, Forsythiae Fructus and Paeoniae Radix Rubra showed 90.0%, 87.4% and 85.1% to compare with amyloid beta (1-42) peptide treated cells (IMR-32), respectively. Three herbs, Moutan Radicis Cortex, Forsythiae Fructus and Paeoniae Radix Rubra are promising candidates from natural products for development of Alzheimer’s disease therapeutics.
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KEYWORD
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Alzheimer’s disease, acetylcholinesterase, amyloid beta(1-42), Moutan Radicis Cortex, Gardeniae Fructus
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